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pc12 neuronal cell lines  (ATCC)


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    ATCC pc12 neuronal cell lines
    Pc12 Neuronal Cell Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 4408 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pc12+neuronal+cell+lines/PC-12/pm41462282-51-4-12
    Average 98 stars, based on 4408 article reviews
    pc12 neuronal cell lines - by Bioz Stars, 2026-09
    98/100 stars

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    Related Articles

    Sulforhodamine B Assay:

    Article Title: Shikonin alleviates rotenone-induced Parkinson's disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production.
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.

    Article Title: Shikonin alleviates rotenone-induced Parkinson’s disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.

    Western Blot:

    Article Title: Shikonin alleviates rotenone-induced Parkinson's disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production.
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.

    Article Title: Shikonin alleviates rotenone-induced Parkinson’s disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.

    Marker:

    Article Title: Shikonin alleviates rotenone-induced Parkinson's disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production.
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.

    Article Title: Shikonin alleviates rotenone-induced Parkinson’s disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.

    Control:

    Article Title: Shikonin alleviates rotenone-induced Parkinson's disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production.
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.

    Article Title: Shikonin alleviates rotenone-induced Parkinson’s disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.

    Expressing:

    Article Title: Shikonin alleviates rotenone-induced Parkinson's disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production.
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.

    Article Title: Shikonin alleviates rotenone-induced Parkinson’s disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.

    TUNEL Assay:

    Article Title: Shikonin alleviates rotenone-induced Parkinson's disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production.
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.

    Article Title: Shikonin alleviates rotenone-induced Parkinson’s disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.

    Staining:

    Article Title: Shikonin alleviates rotenone-induced Parkinson's disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production.
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.

    Article Title: Shikonin alleviates rotenone-induced Parkinson’s disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.

    Flow Cytometry:

    Article Title: Shikonin alleviates rotenone-induced Parkinson's disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production.
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI1640 medium.

    Article Title: Shikonin alleviates rotenone-induced Parkinson’s disease neuroinflammation by targeting PKM2-mediated glycolytic MG-Hs production
    Article Snippet: The BV2 microglial and PC12 neuronal cell lines were procured from the American Type Culture Collection (ATCC, Manassas, VA, USA).. BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.BV2 cells were maintained in high-glucose Dulbecco’s Modified Eagle Medium (HDMEM), while PC12 cells were cultured in RPMI-1640 medium.



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    SHP2 inhibition reduces neuronal apoptosis in the context of SCI. (A, B) NeuN (red-CoraLite594) and SHP2 (green-CoraLite488) immunoreactivities in mice treated with NSC87877 14 days after SCI, as detected by immunofluorescence. Quantitative analysis showing that a decrease in SHP2 fluorescence intensity and an increase in the fluorescence intensity of NeuN, a neuronal marker, in SCI + NSC87877 group mice near the injury site ( n = 5 slices from three mice per group). Scale bars: 50 μm. (C) Nissl staining of mouse spinal cord transverse and longitudinal sections 14 days after SCI showing that, compared with the SCI group, the SCI + NSC87877 group exhibited more Nissl bodies with a more uniform distribution ( n = 5 slices from three mice per group). Scale bars: 100 μm (left), 600 μm (right). (D, E) Western blot analysis of Caspase3, C-caspase3, Bax, and Bcl-2 protein expression in <t>PC12</t> cells co-cultured with BV2 cells treated with LPS or LPS + NSC87877 for 24 hours. The experiment was repeated three times. (F, G) C-caspase3 (red-CoraLite594) expression in PC12 cells was detected by immunofluorescence staining. Quantitative analysis showed decreased immunofluorescence intensity of the apoptosis marker C-caspase3 in neurons co-cultured with BV2 cells from the LPS + NSC87877 group. The experiment was repeated three times. Scale bars: 50 μm. Data are expressed as the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001 (one-way analysis of variance with Bonferroni’s post hoc test). Bax: Bcl-2-associated X protein; Bcl-2: B-cell lymphoma 2; Caspase3: cysteine-aspartic acid protease 3; C-caspase3: cleaved caspase-3; DAPI: 4′,6-diamidino-2′-phenylindole; IF: immunofluorescence staining; LPS: lipopolysaccharide; NeuN: neuronal nuclei; NSC87877: SHP2 inhibitor; SCI: spinal cord injury; SHP2: Src homology 2 domain-containing protein tyrosine phosphatase 2.
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    Image Search Results


    SHP2 inhibition reduces neuronal apoptosis in the context of SCI. (A, B) NeuN (red-CoraLite594) and SHP2 (green-CoraLite488) immunoreactivities in mice treated with NSC87877 14 days after SCI, as detected by immunofluorescence. Quantitative analysis showing that a decrease in SHP2 fluorescence intensity and an increase in the fluorescence intensity of NeuN, a neuronal marker, in SCI + NSC87877 group mice near the injury site ( n = 5 slices from three mice per group). Scale bars: 50 μm. (C) Nissl staining of mouse spinal cord transverse and longitudinal sections 14 days after SCI showing that, compared with the SCI group, the SCI + NSC87877 group exhibited more Nissl bodies with a more uniform distribution ( n = 5 slices from three mice per group). Scale bars: 100 μm (left), 600 μm (right). (D, E) Western blot analysis of Caspase3, C-caspase3, Bax, and Bcl-2 protein expression in PC12 cells co-cultured with BV2 cells treated with LPS or LPS + NSC87877 for 24 hours. The experiment was repeated three times. (F, G) C-caspase3 (red-CoraLite594) expression in PC12 cells was detected by immunofluorescence staining. Quantitative analysis showed decreased immunofluorescence intensity of the apoptosis marker C-caspase3 in neurons co-cultured with BV2 cells from the LPS + NSC87877 group. The experiment was repeated three times. Scale bars: 50 μm. Data are expressed as the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001 (one-way analysis of variance with Bonferroni’s post hoc test). Bax: Bcl-2-associated X protein; Bcl-2: B-cell lymphoma 2; Caspase3: cysteine-aspartic acid protease 3; C-caspase3: cleaved caspase-3; DAPI: 4′,6-diamidino-2′-phenylindole; IF: immunofluorescence staining; LPS: lipopolysaccharide; NeuN: neuronal nuclei; NSC87877: SHP2 inhibitor; SCI: spinal cord injury; SHP2: Src homology 2 domain-containing protein tyrosine phosphatase 2.

    Journal: Neural Regeneration Research

    Article Title: Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

    doi: 10.4103/NRR.NRR-D-23-01925

    Figure Lengend Snippet: SHP2 inhibition reduces neuronal apoptosis in the context of SCI. (A, B) NeuN (red-CoraLite594) and SHP2 (green-CoraLite488) immunoreactivities in mice treated with NSC87877 14 days after SCI, as detected by immunofluorescence. Quantitative analysis showing that a decrease in SHP2 fluorescence intensity and an increase in the fluorescence intensity of NeuN, a neuronal marker, in SCI + NSC87877 group mice near the injury site ( n = 5 slices from three mice per group). Scale bars: 50 μm. (C) Nissl staining of mouse spinal cord transverse and longitudinal sections 14 days after SCI showing that, compared with the SCI group, the SCI + NSC87877 group exhibited more Nissl bodies with a more uniform distribution ( n = 5 slices from three mice per group). Scale bars: 100 μm (left), 600 μm (right). (D, E) Western blot analysis of Caspase3, C-caspase3, Bax, and Bcl-2 protein expression in PC12 cells co-cultured with BV2 cells treated with LPS or LPS + NSC87877 for 24 hours. The experiment was repeated three times. (F, G) C-caspase3 (red-CoraLite594) expression in PC12 cells was detected by immunofluorescence staining. Quantitative analysis showed decreased immunofluorescence intensity of the apoptosis marker C-caspase3 in neurons co-cultured with BV2 cells from the LPS + NSC87877 group. The experiment was repeated three times. Scale bars: 50 μm. Data are expressed as the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001 (one-way analysis of variance with Bonferroni’s post hoc test). Bax: Bcl-2-associated X protein; Bcl-2: B-cell lymphoma 2; Caspase3: cysteine-aspartic acid protease 3; C-caspase3: cleaved caspase-3; DAPI: 4′,6-diamidino-2′-phenylindole; IF: immunofluorescence staining; LPS: lipopolysaccharide; NeuN: neuronal nuclei; NSC87877: SHP2 inhibitor; SCI: spinal cord injury; SHP2: Src homology 2 domain-containing protein tyrosine phosphatase 2.

    Article Snippet: The PC12 neuronal cell line (Cat# CL-0481, RRID:CVCL_0481), and the BV2 mouse microglia cell line (Cat# CL0493, RRID: CVCL_0182) were purchased from Procell Life Science and Technology Co. (Wuhan, China).

    Techniques: Inhibition, Immunofluorescence, Fluorescence, Marker, Staining, Western Blot, Expressing, Cell Culture